Abstract
Mutations in the profilin 1 (PFN1) gene, encoding a member of the profilin family of small actin-binding proteins, have been recently reported in patients with familial amyotrophic lateral sclerosis (ALS). In this study we aimed to determine the prevalence of PFN1 mutations by sequencing the coding region of this gene in a cohort of 94 familial ALS patients from France and Quebec. No mutations were identified in our cohort suggesting that PFN1 gene mutations are a very rare cause of familial ALS among patients with predominantly European ancestry.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amyotrophic Lateral Sclerosis / epidemiology*
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Amyotrophic Lateral Sclerosis / genetics*
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Canada / epidemiology
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DNA Mutational Analysis / statistics & numerical data
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France / epidemiology
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Genetic Markers / genetics
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Genetic Predisposition to Disease / epidemiology*
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Genetic Predisposition to Disease / genetics*
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Humans
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Mutation / genetics*
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Polymorphism, Single Nucleotide / genetics*
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Prevalence
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Profilins / genetics*
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Risk Factors
Substances
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Genetic Markers
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PFN1 protein, human
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Profilins
Supplementary concepts
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Amyotrophic lateral sclerosis 1