Synthesis and antiviral evaluation of alpha-amino acid esters bearing N6-benzyladenine side chain

Acta Pol Pharm. 2012 Sep-Oct;69(5):917-25.

Abstract

A series of peptide derivatives conjugated with a purine residue were synthesized. The prepared compounds were tested for antiviral activity against Hepatitis B Virus (HBV) displaying different degrees of antiviral activities or inhibitory actions.

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / chemistry
  • Adenine / pharmacology*
  • Amino Acids / chemical synthesis*
  • Amino Acids / pharmacology
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology*
  • Esters / chemical synthesis*
  • Esters / pharmacology*
  • Hepatitis B virus / drug effects
  • Peptides / chemical synthesis
  • Peptides / pharmacology
  • Purines / chemistry

Substances

  • Amino Acids
  • Antiviral Agents
  • Esters
  • Peptides
  • Purines
  • Adenine
  • purine