Background: Acute disseminated encephalomyelitis (ADEM) is a rare, monophasic, demyelinating disease of the CNS which sometimes could be refractory to traditional treatment.
Case presentation: We present a case of fulminant ADEM which is treated with combination of corticosteroid, intravenous immunoglobulin and cyclosporine.
Conclusion: Immunosuppressive agents such as cyclosporine may be effective especially in fulminant form of the disease.
Keywords: ADEM; Acute disseminated encephalomyelitis; Cyclosporine; Demyelination.