Synthesis of polysubstituted β-amino cyclohexane carboxylic acids via Diels-Alder reaction using Ni(II)-complex stabilized β-alanine derived dienes

Amino Acids. 2013 Feb;44(2):791-6. doi: 10.1007/s00726-012-1404-x. Epub 2012 Sep 30.

Abstract

This paper describes the design and synthesis of a new class of β-alanine derived dienes stabilized by Ni(II)-complex. Preliminary study of their Diels-Alder cycloaddition reactions with several types of dienophiles demonstrates their significant synthetic potential for the preparation of various polyfunctional β-aminocyclohexane carboxylic acids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids, Cyclic / chemical synthesis*
  • Amino Acids, Cyclic / chemistry
  • Catalysis
  • Cycloaddition Reaction
  • Cyclohexanecarboxylic Acids / chemical synthesis*
  • Cyclohexanecarboxylic Acids / chemistry
  • Molecular Structure
  • Nickel / chemistry*
  • beta-Alanine / chemistry*

Substances

  • Amino Acids, Cyclic
  • Cyclohexanecarboxylic Acids
  • beta-Alanine
  • Nickel