In Denmark, a total of 31,000 assisted reproductive technology (ART) and intrauterine insemination treatments yearly results in the delivery of around 6,300 children, which represents 9% of the Danish birth cohort. The delivery rate following ART (in vitro fertilization/intracytoplasmatic sperm injection, frozen embryo replacement and oocyte donation) has been stable around 20% per cycle initiated during the last decade, despite the transfer of fewer embryos. The future challenges are the increasing age of women seeking fertility treatment, the development of biomarkers of embryonic implantation potential as well as the improvement of embryo culture, and embryo freezing techniques.