Nanoengineered colloidal probes for Raman-based detection of biomolecules inside living cells

Alexey Yashchenok; Admir Masic; Dmitry Gorin; Bong Sup Shim; Nicholas A Kotov; Peter Fratzl; Helmuth Möhwald; Andre Skirtach

doi:10.1002/smll.201201494

Nanoengineered colloidal probes for Raman-based detection of biomolecules inside living cells

Small. 2013 Feb 11;9(3):351-6. doi: 10.1002/smll.201201494. Epub 2012 Oct 9.

Authors

Alexey Yashchenok¹, Admir Masic, Dmitry Gorin, Bong Sup Shim, Nicholas A Kotov, Peter Fratzl, Helmuth Möhwald, Andre Skirtach

Affiliation

¹ Max Planck Institute of Colloids and Interfaces, Department of Interfaces, Potsdam, Germany.

PMID: 23047321
DOI: 10.1002/smll.201201494

Abstract

Gold nanoparticle aggregate carbon nanotube functionalized colloidal particles serve as an efficient platform for probing the intracellular environment. The probes provide the means of effective localization of signal and detection of molecular fingerprints of biomolecules in living cells. The approach demonstrated in this work opens significant opportunities in molecular imaging as well as intracellular sensing and trafficking.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Gold / chemistry*
Metal Nanoparticles / chemistry*
Nanotubes, Carbon / chemistry
Spectrum Analysis, Raman / methods*

Substances

Nanotubes, Carbon
Gold