Dually cationic and anionic pH/temperature-sensitive injectable hydrogels and potential application as a protein carrier

Cong Truc Huynh; Minh Khanh Nguyen; Doo Sung Lee

doi:10.1039/c2cc36134e

Dually cationic and anionic pH/temperature-sensitive injectable hydrogels and potential application as a protein carrier

Chem Commun (Camb). 2012 Nov 18;48(89):10951-3. doi: 10.1039/c2cc36134e.

Authors

Cong Truc Huynh¹, Minh Khanh Nguyen, Doo Sung Lee

Affiliation

¹ Theranostic Macromolecules Research Center, Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, South Korea.

PMID: 23042037
DOI: 10.1039/c2cc36134e

Abstract

Novel copolymers containing both anionic and cationic pH-sensitive moieties were reported. These amphoteric copolymers exhibited special closed-loop reversible sol-gel-sol phase transitions in response to both pH and temperature.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anions
Cations
Drug Delivery Systems*
Hydrogels*
Hydrogen-Ion Concentration
Models, Molecular
Phase Transition
Proteins / chemistry*
Temperature

Substances

Anions
Cations
Hydrogels
Proteins