Tri-G-quadruplex: controlled assembly of a G-quadruplex structure from three G-rich strands

Angew Chem Int Ed Engl. 2012 Oct 29;51(44):11002-5. doi: 10.1002/anie.201205390. Epub 2012 Oct 4.

Abstract

In my (DNA) dreams: A tri-G-quadruplex was constructed from three strands (T1-T3) of DNA using duplex formation to guide the G-rich tracts into close proximity with the addition of Li(+) ions (see scheme). The defined G-quadruplex structure was formed upon addition of Na(+) ions and characterized by gel electrophoresis and spectroscopy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / chemical synthesis*
  • DNA / chemistry*
  • G-Quadruplexes*
  • Guanine / chemistry*
  • Oligonucleotides / chemical synthesis
  • Oligonucleotides / chemistry*

Substances

  • Oligonucleotides
  • Guanine
  • DNA