Nanoparticles and peptides: a fruitful liaison for biomimetic catalysis

Angew Chem Int Ed Engl. 2012 Nov 5;51(45):11202-4. doi: 10.1002/anie.201206373. Epub 2012 Oct 4.

Abstract

Inspired by nature: self-assembled peptide nanoparticles have been designed that accelerate ester hydrolysis (see picture; Cbz=carbobenzyloxy, NP=p-NO(2)-C(6) H(4)). The concerted interplay of the multivalent surface with the catalytically active peptide and the substrate at the same time combines several aspects decisive for the catalyst's efficiency, a property characteristic of enzymes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomimetic Materials / chemistry*
  • Biomimetic Materials / metabolism
  • Biomimetics
  • Catalysis
  • Esters / chemistry*
  • Esters / metabolism
  • Metal Nanoparticles / chemistry*
  • Peptides / chemistry*
  • Peptides / metabolism
  • Silver / chemistry

Substances

  • Esters
  • Peptides
  • Silver