pH-responsive size-tunable self-assembled DNA dendrimers

Angew Chem Int Ed Engl. 2012 Nov 5;51(45):11271-4. doi: 10.1002/anie.201205862. Epub 2012 Oct 4.

Abstract

Putting the DNA in dendrimers: a strategy to swiftly prepare DNA dendrimers based solely on DNA self-assembly is presented. This technique produces highly pure DNA dendrimers with an excellent yield of high generation dendrimers. The incorporation of molecular motors (i-motifs) into the DNA dendrimers allows for a change in size (up to 30%) in response to changing pH values.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Circular Dichroism
  • DNA / chemical synthesis
  • DNA / chemistry*
  • Dendrimers / chemical synthesis
  • Dendrimers / chemistry*
  • Electrophoresis, Agar Gel
  • Hydrogen-Ion Concentration
  • Light
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • Scattering, Radiation

Substances

  • Dendrimers
  • DNA