We report on the development of UV range photodetector based on molybdenum disulfide nanocrystals (MoS₂-NCs). The inorganic MoS₂-NCs are produced by pulsed laser ablation technique in deionized water and the colloidal MoS₂-NCs are characterized by transmission electron microscopy, Raman spectroscopy, X-ray diffraction and UV/VIS absorption measurements. The photoresponse studies indicate that the fabricated MoS₂-NCs photodetector (MoS₂-NCs PD) operates well within 300-400 nm UV range, with diminishing response at visible wavelengths, due to the MoS₂-NCs absorption characteristics. The structural and the optical properties of laser generated MoS₂-NCs suggest promising applications in the field of photonics and optoelectronics.