Artificial cytoskeletal structures within enzymatically active bio-inorganic protocells

Ravinash Krishna Kumar; Mei Li; Sam N Olof; Avinash J Patil; Stephen Mann

doi:10.1002/smll.201201539

Artificial cytoskeletal structures within enzymatically active bio-inorganic protocells

Small. 2013 Feb 11;9(3):357-62. doi: 10.1002/smll.201201539. Epub 2012 Oct 2.

Authors

Ravinash Krishna Kumar¹, Mei Li, Sam N Olof, Avinash J Patil, Stephen Mann

Affiliation

¹ Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol, UK.

PMID: 23027575
DOI: 10.1002/smll.201201539

Abstract

The fabrication of enzymatically active, semi-permeable bio-inorganic protocells capable of self-assembling a cytoskeletal-like interior and undergoing small-molecule dephosphorylation reactions is described. Reversible disassembly of an amino acid-derived supramolecular hydrogel within the internalized reaction space is used to tune the enzymatic activity of the nanoparticle-bounded inorganic compartments.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Artificial Cells / chemistry*
Enzymes / chemistry
Enzymes / metabolism*
Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
Nanoparticles / chemistry*

Substances

Enzymes
Hydrogel, Polyethylene Glycol Dimethacrylate