Fumagillin-induced aseptic meningoencephalitis in a kidney transplant recipient with microsporidiosis

Transpl Infect Dis. 2012 Dec;14(6):E147-9. doi: 10.1111/tid.12010. Epub 2012 Oct 2.

Abstract

Microsporidiosis is an opportunistic infection in organ transplant recipients and patients with other cellular immunodeficiency. Fumagillin is an effective treatment against Enterocytozoon bieneusi, one of the two main species causing the microsporidiosis involved in human diseases. We report the first case, to our knowledge, of a probable drug-induced aseptic meningoencephalitis, after administration of fumagillin in a kidney transplant recipient with microsporidiosis.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / adverse effects*
  • Cyclohexanes / adverse effects*
  • Cyclohexanes / therapeutic use
  • Fatty Acids, Unsaturated / adverse effects*
  • Fatty Acids, Unsaturated / therapeutic use
  • Female
  • Humans
  • Immunocompromised Host
  • Kidney Transplantation / adverse effects*
  • Meningoencephalitis / etiology*
  • Microsporidiosis / drug therapy*
  • Middle Aged
  • Sesquiterpenes / adverse effects
  • Sesquiterpenes / therapeutic use

Substances

  • Antifungal Agents
  • Cyclohexanes
  • Fatty Acids, Unsaturated
  • Sesquiterpenes
  • fumagillin