Xentrivalpeptides A-Q: depsipeptide diversification in Xenorhabdus

J Nat Prod. 2012 Oct 26;75(10):1717-22. doi: 10.1021/np300279g. Epub 2012 Oct 1.

Abstract

Seventeen depsipeptides, xentrivalpeptides A-Q (1-17), have been identified from an entomopathogenic Xenorhabdus sp. Whereas the structure of xentrivalpeptide A (1) was determined after its isolation by NMR spectroscopy and the advanced Marfey's method, the structures of all other derivatives were determined using a combination of stable isotope labeling and detailed MS analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Depsipeptides / chemistry
  • Depsipeptides / isolation & purification*
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Xenorhabdus / chemistry*

Substances

  • Depsipeptides
  • xentrivalpeptide A
  • romidepsin