Abstract
Highly functionalized dihydropyridinones were synthesized via the N-heterocyclic carbene-catalyzed enantioselective [4 + 2] annulation of α-chloroaldehydes and azadienes. Hydrogenation of the resulted dihydropyridinones afforded the corresponding piperidinones with high enantiopurity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aldehydes / chemistry*
-
Aza Compounds / chemistry*
-
Cyclization
-
Hydrogenation
-
Methane / analogs & derivatives*
-
Methane / chemistry
-
Molecular Structure
-
Pyridones / chemistry*
-
Stereoisomerism
Substances
-
Aldehydes
-
Aza Compounds
-
Pyridones
-
carbene
-
Methane