Bradykinin receptors are an important member of the G protein-coupled receptors family. Bradykinin receptor-mediated signal transductions play a significant role in maintaining cardiovascular homeostasis, regulating pain and inflammation. In recent years, the introduction of fluorescence resonance energy transfer, bioluminescence resonance energy transfer and their extended technologies, confirmed that bradykinin receptors can exist in the formation of dimerizations or even high-order oligomers. Compared with the monomer, its signal transduction and pathological features have changed accordingly. In this paper, we overview how bradykinin receptor monomeric and dimers regulate physiological and pathological processes as well as the latest research techniques.