Antimicrobial and antifouling hydrogels formed in situ from polycarbonate and poly(ethylene glycol) via Michael addition

Adv Mater. 2012 Dec 18;24(48):6484-9. doi: 10.1002/adma.201202225. Epub 2012 Sep 27.

Abstract

A novel class of antimicrobial cationic polycarbonate/PEG hydrogels are designed and synthesized by Michael addition chemistry. These hydrogels demonstrate strong broad-spectrum antimicrobial activities against various clinically isolated multidrug-resistant microbes. Moreover, they exhibit nonfouling properties and prevent the substrate from microbial adhesion. These antimicrobial and antifouling gels are promising materials as catheter coatings and wound dressings to prevent infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Biofouling / prevention & control*
  • Candida albicans / drug effects
  • Dose-Response Relationship, Drug
  • Escherichia coli / drug effects
  • Hydrogels / chemical synthesis
  • Hydrogels / chemistry
  • Hydrogels / pharmacology*
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Structure
  • Polycarboxylate Cement / chemical synthesis
  • Polycarboxylate Cement / chemistry
  • Polycarboxylate Cement / pharmacology*
  • Polyethylene Glycols / chemical synthesis
  • Polyethylene Glycols / chemistry
  • Polyethylene Glycols / pharmacology*
  • Staphylococcus aureus / drug effects
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Hydrogels
  • Polycarboxylate Cement
  • polycarbonate
  • Polyethylene Glycols