Abstract
A novel class of antimicrobial cationic polycarbonate/PEG hydrogels are designed and synthesized by Michael addition chemistry. These hydrogels demonstrate strong broad-spectrum antimicrobial activities against various clinically isolated multidrug-resistant microbes. Moreover, they exhibit nonfouling properties and prevent the substrate from microbial adhesion. These antimicrobial and antifouling gels are promising materials as catheter coatings and wound dressings to prevent infections.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Biofouling / prevention & control*
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Candida albicans / drug effects
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Dose-Response Relationship, Drug
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Escherichia coli / drug effects
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Hydrogels / chemical synthesis
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Hydrogels / chemistry
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Hydrogels / pharmacology*
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Microbial Sensitivity Tests
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Models, Molecular
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Molecular Structure
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Polycarboxylate Cement / chemical synthesis
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Polycarboxylate Cement / chemistry
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Polycarboxylate Cement / pharmacology*
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Polyethylene Glycols / chemical synthesis
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Polyethylene Glycols / chemistry
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Polyethylene Glycols / pharmacology*
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Staphylococcus aureus / drug effects
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Hydrogels
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Polycarboxylate Cement
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polycarbonate
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Polyethylene Glycols