[Peripheral mechanisms of action of oxatriazolium-5-olate derivative 3-(3-[1,2,4]-triazolo)oxatriazolium-5-olate in spontaneously hypertensive rats]

M M Artem'eva; A B Postnikov; O V Akinfieva; I L Daliger; S A Shevelev; O S Medvedev; N A Medvedeva

[Peripheral mechanisms of action of oxatriazolium-5-olate derivative 3-(3-[1,2,4]-triazolo)oxatriazolium-5-olate in spontaneously hypertensive rats]

Eksp Klin Farmakol. 2012;75(8):11-4.

[Article in Russian]

Authors

M M Artem'eva, A B Postnikov, O V Akinfieva, I L Daliger, S A Shevelev, O S Medvedev, N A Medvedeva

PMID: 23012989

Abstract

It is shown that 3-(3-[1,2,4]-triazolo)-oxatriazolium-5-olate (azasidnon-6) can act directly on the vascular wall of isolated segments of caudal ventral artery of SHR rats. Using heme-dependent soluble guanyl cyclase inhibitor 1H-[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), it has been found that one of the possible mechanisms of azasidnon-6 vasodilatory action includes heme-dependent activation of a soluble form of guanylate cyclase.

Publication types

English Abstract

MeSH terms

Animals
Arteries / drug effects*
Guanylate Cyclase / antagonists & inhibitors
Guanylate Cyclase / metabolism
Heme / metabolism
Male
Nitric Oxide / metabolism
Nitroprusside / pharmacology
Oxadiazoles / pharmacology
Phenylephrine / pharmacology
Quinoxalines / pharmacology
Rats
Rats, Inbred SHR
Rats, Wistar
Tail / blood supply
Tissue Culture Techniques
Triazoles / pharmacology*
Vasoconstrictor Agents / pharmacology
Vasodilation / drug effects*
Vasodilator Agents / pharmacology*

Substances

1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one
3-(3-(1,2,4)-triazolo)-oxatriazolium-5-olate
Oxadiazoles
Quinoxalines
Triazoles
Vasoconstrictor Agents
Vasodilator Agents
Nitroprusside
Phenylephrine
Nitric Oxide
Heme
Guanylate Cyclase