[Telangiectatic osteosarcoma secondary to a liposclerosing myxofibrous tumor: a case report]

Ann Pathol. 2012 Aug;32(4):259-62. doi: 10.1016/j.annpat.2012.06.003. Epub 2012 Jul 21.
[Article in French]

Abstract

Malignant transformation of a fibrous dysplasia into an osteosarcoma is very rare. We report the case of an 84-year-old man with telangiectatic osteosarcoma of the upper femur arising in a previous fibrous dysplasia also known as liposclerosing myxofibrous tumor. The tumor was expressing the epithelial membrane antigen. This is the first described case of a malignant transformation into an osteosarcoma arising in a liposclerosing myxofibrous tumor. We discuss the main differential diagnosis with a review.

Publication types

  • Case Reports
  • English Abstract
  • Review

MeSH terms

  • Aged, 80 and over
  • Biomarkers, Tumor / analysis
  • Bone Cysts / etiology
  • Bone Cysts / pathology
  • Diagnosis, Differential
  • Disease Progression
  • Femoral Neoplasms / blood supply
  • Femoral Neoplasms / chemistry
  • Femoral Neoplasms / diagnosis
  • Femoral Neoplasms / pathology*
  • Femoral Neoplasms / surgery
  • Fibrous Dysplasia of Bone
  • Hemorrhage / etiology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Mucin-1 / analysis
  • Neoplasms, Second Primary / blood supply
  • Neoplasms, Second Primary / chemistry
  • Neoplasms, Second Primary / diagnosis
  • Neoplasms, Second Primary / pathology*
  • Neoplasms, Second Primary / surgery
  • Osteosarcoma / blood supply
  • Osteosarcoma / chemistry
  • Osteosarcoma / diagnosis
  • Osteosarcoma / pathology*
  • Osteosarcoma / surgery
  • Solitary Fibrous Tumors / chemistry
  • Solitary Fibrous Tumors / pathology*
  • Telangiectasis / pathology*

Substances

  • Biomarkers, Tumor
  • Mucin-1