Abstract
Not in the public domain: Site-directed mutagenesis of megasynthases was the key to the generation of a library of polyketides in bacteria. Redox derivatizations are used to change the bioactivity profile of the compounds.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Magnetic Resonance Spectroscopy
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Mutagenesis
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Oxidation-Reduction
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Polyketide Synthases / genetics*
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Polyketide Synthases / metabolism*
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Polyketides / chemical synthesis*
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Polyketides / chemistry
Substances
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Polyketides
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Polyketide Synthases