Direct lineage conversion: induced neuronal cells and induced neural stem cells

Protein Cell. 2012 Nov;3(11):826-33. doi: 10.1007/s13238-012-2068-8. Epub 2012 Sep 21.

Abstract

Cellular reprogramming to neural cells is an area of ongoing study in developmental neuroscience, and recent research has generated remarkable achievements. Several studies have shown that the ectopic expression of specific neural transcription factors can convert terminally differentiated cells into neural cells. Here, we review the most recent progress in the field of induced neuronal (iN) cells and induced neural stem (iNS) cells and their potential clinical applications.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Humans
  • Induced Pluripotent Stem Cells / cytology
  • Induced Pluripotent Stem Cells / metabolism
  • Neural Stem Cells / cytology*
  • Neurons / cytology*
  • Neurons / metabolism
  • Transcription Factors / metabolism

Substances

  • Transcription Factors