OPA1 mutations induce mtDNA proliferation in leukocytes of patients with dominant optic atrophy

MeSH terms

• Cell Proliferation
• Cohort Studies
• DNA Copy Number Variations / genetics
• DNA, Mitochondrial / genetics*
• England
• Female
• GTP Phosphohydrolases / genetics*
• Germany
• Humans
• Leukocytes / metabolism*
• Male
• Mutation / genetics*
• Netherlands
• Optic Atrophy, Autosomal Dominant / genetics*
• Optic Atrophy, Autosomal Dominant / pathology*
• Visual Acuity / genetics