Abstract
Various newly prepared and previously known vitamin B₁₂ derivatives have been studied as potential soluble guanylyl cyclase (sGC) activators. All compounds tested were found to activate the sGC enzyme, although to differing extents. The best results were obtained with the derivatives synthesized from c-lactone and possessing aliphatic amides in the c- and d-positions.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemical synthesis
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Amides / chemistry
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Enzyme Activators / chemical synthesis*
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Enzyme Activators / chemistry
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Guanylate Cyclase / chemistry*
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Humans
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Lactones / chemical synthesis*
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Lactones / chemistry
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Receptors, Cytoplasmic and Nuclear / chemistry*
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Soluble Guanylyl Cyclase
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Structure-Activity Relationship
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Vitamin B 12 / analogs & derivatives*
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Vitamin B 12 / chemical synthesis*
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Vitamin B 12 / chemistry
Substances
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Amides
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Enzyme Activators
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Lactones
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Receptors, Cytoplasmic and Nuclear
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Guanylate Cyclase
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Soluble Guanylyl Cyclase
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Vitamin B 12