Pd(OAc)2 catalyzed direct arylation of electron-deficient arenes without ligands or with monoprotected amino acid assistance

Chem Commun (Camb). 2012 Oct 28;48(84):10437-9. doi: 10.1039/c2cc34949c. Epub 2012 Sep 19.

Abstract

An efficient arylation of electron-poor arenes has been developed without the addition of external ligands or in the presence of a catalytic monoprotected amino acid which assisted the reaction to proceed under mild conditions. The meta-selectivity was observed under both conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetates / chemistry*
  • Amino Acids / chemistry*
  • Catalysis
  • Electrons
  • Hydrocarbons, Brominated / chemistry*
  • Hydrocarbons, Fluorinated / chemical synthesis
  • Hydrocarbons, Fluorinated / chemistry*
  • Ligands
  • Molecular Structure
  • Organometallic Compounds / chemistry*

Substances

  • Acetates
  • Amino Acids
  • Hydrocarbons, Brominated
  • Hydrocarbons, Fluorinated
  • Ligands
  • Organometallic Compounds
  • palladium(II) acetate