The first synthesis of Krempene B

Steroids. 2012 Nov;77(13):1398-402. doi: 10.1016/j.steroids.2012.08.006. Epub 2012 Aug 31.

Abstract

The synthesis of Krempene B, which can be isolated from the marine soft coral Cladiella krempfi, is achieved in 23.9% overall yield from commercially available 3β-acetoxy-5-pregnen-20-one by 11 steps. Key transformations include the dienone-phenol rearrangement of steroids and Wittig reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Products / chemical synthesis*
  • Biological Products / chemistry
  • Chemistry Techniques, Synthetic
  • Diterpenes / chemical synthesis*
  • Diterpenes / chemistry
  • Steroids / chemistry

Substances

  • Biological Products
  • Diterpenes
  • Steroids