Relief of intractable posthypoxic myoclonus after administration of agomelatine

Clin Neuropharmacol. 2012 Sep-Oct;35(5):258-9. doi: 10.1097/WNF.0b013e3182613e06.

Abstract

Chronic posthypoxic myoclonus is characterized by myoclonic jerks that are specifically triggered by action. It is a rare but devastating sequela of hypoxic encephalopathy. We report a 42-year-old female patient with treatment-resistant chronic posthypoxic myoclonus, which improved with administration of the drug agomelatine. We suggest that agomelatine could represent a useful therapeutic option in the treatment of chronic posthypoxic myoclonus.

Publication types

  • Case Reports

MeSH terms

  • Acetamides / pharmacology
  • Acetamides / therapeutic use*
  • Adult
  • Female
  • Humans
  • Hypoxia, Brain / complications
  • Hypoxia, Brain / diagnosis*
  • Hypoxia, Brain / drug therapy*
  • Melatonin / agonists*
  • Myoclonus / diagnosis*
  • Myoclonus / drug therapy*
  • Myoclonus / etiology

Substances

  • Acetamides
  • agomelatine
  • Melatonin