Deciphering DNA-based asymmetric catalysis through intramolecular Friedel-Crafts alkylations

Chem Commun (Camb). 2012 Oct 28;48(84):10398-400. doi: 10.1039/c2cc35625b. Epub 2012 Sep 17.

Abstract

We describe asymmetric intramolecular Friedel-Crafts alkylations with a DNA-based hybrid catalyst and propose a plausible binding model. This study shows promise for studying relationships between the helical chirality of DNA and enantioselectivity of the chemical reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Catalysis
  • Copper / chemistry
  • DNA / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Pyridines / chemistry
  • Stereoisomerism

Substances

  • 4,4'-dimethyl-2,2'-bipyridine
  • Organometallic Compounds
  • Pyridines
  • Copper
  • DNA