Abstract
Benzoylphloroglucinol derivatives are natural products showing diverse biological activities that could be modulated by structural modifications. For this purpose, we studied the biotransformation of guttiferone A and of maclurin using a combinatorial approach for screening active microorganism strains. We found a novel and unexpected yeast-catalyzed oxidation that has selectively given a new oxy-guttiferone A and norathyriol.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / chemistry*
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Antimalarials / metabolism
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Antimalarials / pharmacology
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Biocatalysis
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Cell Survival / drug effects
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Chlorocebus aethiops
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Cyclization
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Molecular Structure
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Oxidation-Reduction
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Plasmodium falciparum / drug effects
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Trypanosoma brucei brucei / drug effects
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Vero Cells
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Xanthones / chemistry*
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Xanthones / metabolism
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Xanthones / pharmacology
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Yeasts / chemistry*
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Yeasts / metabolism
Substances
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Antimalarials
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Xanthones
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xanthone