Biological self-assembly of injectable hydrogel as cell scaffold via specific nucleobase pairing

Chem Commun (Camb). 2012 Oct 25;48(83):10289-91. doi: 10.1039/c2cc35449g.

Abstract

A biological hydrogel was self-assembled via Watson-Crick base pairing of thymine and adenine from functionalized star poly(ethylene glycol). Our work should provide a novel methodology to generate robust injectable scaffolds with tailorable properties for biomedical applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine / chemistry
  • Adenine / metabolism*
  • Base Pairing
  • Cell Proliferation
  • Dexamethasone / metabolism
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemical synthesis
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry
  • Hydrogel, Polyethylene Glycol Dimethacrylate / metabolism*
  • Hydrogen Bonding
  • Insulin / metabolism
  • Molecular Structure
  • Polyethylene Glycols / chemical synthesis
  • Polyethylene Glycols / chemistry
  • Polyethylene Glycols / metabolism*
  • Stem Cells / metabolism
  • Temperature
  • Thymine / chemistry
  • Thymine / metabolism*
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Insulin
  • Vascular Endothelial Growth Factor A
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Polyethylene Glycols
  • Dexamethasone
  • Adenine
  • Thymine