Abstract
A mild and efficient Pd-catalyzed cyclopropanation of norbornene derivatives with tertiary propargylic alcohols using molecular oxygen as the sole oxidant is described. This process allows quick and atom-economical assembly of various 1,2,3-trisubstituted cyclopropanes bearing α,β-unsaturated ketone moieties in high yields as a single regio- and diastereoisomer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Cyclopropanes / chemistry*
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Molecular Structure
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Norbornanes / chemical synthesis*
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Norbornanes / chemistry
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Organometallic Compounds / chemistry*
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Oxidants / chemistry*
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Oxygen / chemistry*
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Palladium / chemistry*
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Stereoisomerism
Substances
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Cyclopropanes
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Norbornanes
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Organometallic Compounds
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Oxidants
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Palladium
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Oxygen