Objectives: The aim of this study was to explore the in vivo effect of the plasma aluminum content on lymphocyte DNA damage, the plasma protein carbonyl (PC) content, and malondialdehyde (MDA) and total antioxidative capacity (TAC) levels in aluminum exposed and non-exposed humans.
Design and methods: Peripheral blood samples were collected from in vivo aluminum exposed and non-exposed humans and the above parameters were measured.
Results: The mean values of lymphocyte DNA damage, plasma MDA, PC levels, and aluminum concentrations were found to be significantly higher in the aluminum exposed group than within the control group (p<0.01). On the other hand, plasma TAC levels were found to be significantly lower in the aluminum exposed group than in the control group (p<0.001). Significant positive correlations were found to exist between lymphocyte DNA damage and the aluminum concentration (r=0.643, p<0.001), DNA damage and MDA (r=0.491, p<0.001), and DNA damage and PC (r=0.548, p<0.01). A negative correlation was found between TAC and DNA damage (r=-0.600 p<0.001) in the aluminum exposed group.
Conclusion: Findings from the study revealed that an increased plasma aluminum concentration was associated with increased oxidative stress and increased DNA damage in aluminum exposed humans.
Copyright © 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.