No genetic evidence for Neuregulin 3 conferring risk of schizophrenia in the Chinese population

Psychiatry Res. 2013 Feb 28;205(3):279-81. doi: 10.1016/j.psychres.2012.08.017. Epub 2012 Sep 13.

Abstract

We genotyped 13 single nucleotide polymorphisms (SNPs) within Neuregulin 3 (NRG3) to investigate the association between NRG3 and schizophrenia in 488 patients and 506 controls in Northwest China. No association was detected either in SNPs or in haplotypes. Our study provided no evidence that NRG3 confers a risk of schizophrenia susceptibility in the Han Chinese population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asian People / genetics
  • China
  • Female
  • Genetic Association Studies
  • Genotype
  • Haplotypes
  • Humans
  • Male
  • Neuregulins / genetics
  • Neuregulins / physiology*
  • Polymorphism, Single Nucleotide / genetics*
  • Schizophrenia / genetics*

Substances

  • NRG3 protein, human
  • Neuregulins