Proteasome activity and their subunit composition in endometrial cancer tissue: correlations with clinical morphological parameters

L V Spirina; I V Kondakova; V D Koval'; L A Kolomiets; A L Chernyshova; E L Choinzonov; N P Sharova

doi:10.1007/s10517-012-1751-3

Proteasome activity and their subunit composition in endometrial cancer tissue: correlations with clinical morphological parameters

Bull Exp Biol Med. 2012 Aug;153(4):501-4. doi: 10.1007/s10517-012-1751-3.

[Article in English, Russian]

Authors

L V Spirina¹, I V Kondakova, V D Koval', L A Kolomiets, A L Chernyshova, E L Choinzonov, N P Sharova

Affiliation

¹ Institute of Oncology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. SpirinaLV@oncology.tomsk.ru

PMID: 22977855
DOI: 10.1007/s10517-012-1751-3

Abstract

The development of endometrial cancer is related to the status of the intracellular proteasome system. Total proteasome activity and pools 26S and 20S activities are higher in tumor tissue than in intact endometrium, and their composition is different. The expression of α1α2α3α5α6α7 is lower in endometrial cancer tissue in comparison with intact endometrium and the content of immune subunits LMP7, LMP2, and PA28β is increased. Total proteasome activity depends on the disease stage.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Electrophoresis
Endometrial Neoplasms / metabolism*
Endometrial Neoplasms / pathology*
Endometrium / metabolism*
Female
Humans
Middle Aged
Proteasome Endopeptidase Complex / metabolism*
Protein Subunits / metabolism*
Statistics, Nonparametric

Substances

Protein Subunits
Proteasome Endopeptidase Complex