Effect of NF-κB inhibitor aurothiomalate on local inflammation in experimental Th1- and Th2-type immune response
Bull Exp Biol Med. 2012 Aug;153(4):472-4.
doi: 10.1007/s10517-012-1743-3.
[Article in
English,
Russian]
Affiliation
- 1 Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. vittelli@mail.ru
Abstract
We compared the effect of NF-κB inhibitor aurothiomalate and voltaren on local inflammation in different types of immune response. Both substances reduced edema caused by sheep erythrocytes (Th1-type immune response) and local immediate-type hypersensitivity response induced with ovalbumin (Th2-dependent response). The anti-inflammatory effects of aurothiomalate were similar to those of voltaren during Th1-type immune response.
MeSH terms
-
Analysis of Variance
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Animals
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Cytokines / immunology
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Diclofenac / pharmacology
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Diclofenac / therapeutic use
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Erythrocytes
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Female
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Gold Sodium Thiomalate / pharmacology*
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Gold Sodium Thiomalate / therapeutic use
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Hypersensitivity, Delayed / chemically induced
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Hypersensitivity, Delayed / drug therapy*
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Hypersensitivity, Immediate / chemically induced
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Hypersensitivity, Immediate / drug therapy*
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Immunity, Cellular / immunology*
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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NF-kappa B / antagonists & inhibitors*
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Ovalbumin / toxicity
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Th1 Cells / immunology*
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Th2 Cells / immunology*
Substances
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Cytokines
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NF-kappa B
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Gold Sodium Thiomalate
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Diclofenac
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Ovalbumin