Endogenous regulators of NO bioavailability in rats with acute renal failure
Bull Exp Biol Med. 2012 Aug;153(4):444-7.
doi: 10.1007/s10517-012-1736-2.
[Article in
English,
Russian]
Affiliation
- 1 Laboratory for the Regulation of Adaptation Processes, Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. suhovershin@physiol.ru
Abstract
We studied the impact of acute glycerol-induced renal failure on blood levels and daily urinary excretion of arginine, monomethylarginine, and asymmetric and symmetric dimethylarginine. Acute renal failure was accompanied by enhanced daily excretion of asymmetric and symmetric dimethylarginine, increased plasma level of symmetric dimethylarginine, and decreased plasma level of arginine. Reabsorption of arginine and its methylated analogues decreased, thus compensating for reduced glomerular filtration rate. These data attest to increased production of dimethylarginines during acute renal failure. These changes can decrease NO bioavailability.
MeSH terms
-
Acute Kidney Injury / blood*
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Acute Kidney Injury / chemically induced
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Acute Kidney Injury / urine*
-
Analysis of Variance
-
Animals
-
Arginine / analogs & derivatives
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Arginine / blood
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Arginine / metabolism*
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Arginine / urine
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Biological Availability
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Chromatography, High Pressure Liquid
-
Cluster Analysis
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Glycerol / administration & dosage
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Glycerol / toxicity
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Injections, Intramuscular
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Male
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Nitric Oxide / pharmacokinetics*
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Rats
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Rats, Wistar
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Statistics, Nonparametric
Substances
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dimethylarginine
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Nitric Oxide
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Arginine
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Glycerol