Abstract
6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one is a potent drug-like G protein-coupled receptor 119 (GPR119) agonist. It is hoped that this compound would be instrumental in probing the pharmacological potential of GPR119 agonists.
MeSH terms
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Animals
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Cell Line
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Glucose Tolerance Test
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Humans
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Indenes / chemical synthesis
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Indenes / chemistry*
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Indenes / pharmacokinetics
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Indenes / pharmacology*
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Male
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Mice
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Mice, Inbred C57BL
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Piperidines / chemical synthesis
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Piperidines / chemistry*
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Piperidines / pharmacokinetics
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Piperidines / pharmacology*
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Rats
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Rats, Wistar
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Receptors, G-Protein-Coupled / agonists*
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Receptors, G-Protein-Coupled / metabolism
Substances
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GPR119 protein, human
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Indenes
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Piperidines
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Receptors, G-Protein-Coupled