Synthesis and pharmacological profile of a new selective G protein-coupled receptor 119 agonist; 6-((2-fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one

Chem Pharm Bull (Tokyo). 2012;60(9):1093-5. doi: 10.1248/cpb.c12-00484.

Abstract

6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one is a potent drug-like G protein-coupled receptor 119 (GPR119) agonist. It is hoped that this compound would be instrumental in probing the pharmacological potential of GPR119 agonists.

MeSH terms

  • Animals
  • Cell Line
  • Glucose Tolerance Test
  • Humans
  • Indenes / chemical synthesis
  • Indenes / chemistry*
  • Indenes / pharmacokinetics
  • Indenes / pharmacology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Piperidines / chemical synthesis
  • Piperidines / chemistry*
  • Piperidines / pharmacokinetics
  • Piperidines / pharmacology*
  • Rats
  • Rats, Wistar
  • Receptors, G-Protein-Coupled / agonists*
  • Receptors, G-Protein-Coupled / metabolism

Substances

  • GPR119 protein, human
  • Indenes
  • Piperidines
  • Receptors, G-Protein-Coupled