A synergistically enhanced T(1) -T(2) dual-modal contrast agent

Adv Mater. 2012 Dec 4;24(46):6223-8. doi: 10.1002/adma.201203169. Epub 2012 Sep 13.

Abstract

Monodisperse Gd(2) O(3) -embedded iron oxide (GdIO) nanoparticles can simultaneously enhance the local magnetic field intensities of each other under an external magnetic field and result in synergistic enhancement of T(1) and T(2) effects. GdIO nanoparticles have the unique property to be both T(1) and T(2) contrast agents and can potentially lead to higher accuracy in cancer diagnosis, particularly liver tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Survival / drug effects
  • Contrast Media / chemistry*
  • Contrast Media / toxicity
  • Ferric Compounds / chemistry
  • Gadolinium / chemistry
  • HeLa Cells
  • Hep G2 Cells
  • Humans
  • Liver Neoplasms / diagnostic imaging
  • Magnetic Resonance Imaging
  • Magnetics
  • Metal Nanoparticles / chemistry
  • Metal Nanoparticles / toxicity
  • Mice
  • Radiography

Substances

  • Contrast Media
  • Ferric Compounds
  • ferric oxide
  • gadolinium oxide
  • Gadolinium