Ceria nanoparticles that can protect against ischemic stroke

Angew Chem Int Ed Engl. 2012 Oct 29;51(44):11039-43. doi: 10.1002/anie.201203780. Epub 2012 Sep 11.

Abstract

Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Ischemia / drug therapy
  • Brain Ischemia / metabolism
  • Brain Ischemia / prevention & control*
  • CHO Cells
  • Cell Death / drug effects
  • Cell Survival / drug effects
  • Cerium / administration & dosage
  • Cerium / chemistry
  • Cerium / pharmacology*
  • Cricetinae
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Free Radical Scavengers / administration & dosage
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / pharmacology*
  • Metal Nanoparticles / administration & dosage
  • Metal Nanoparticles / chemistry*
  • Rats
  • Reactive Oxygen Species / metabolism
  • Stroke / drug therapy
  • Stroke / metabolism
  • Stroke / prevention & control*
  • Tissue Distribution

Substances

  • Free Radical Scavengers
  • Reactive Oxygen Species
  • Cerium