Abstract
Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain Ischemia / drug therapy
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Brain Ischemia / metabolism
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Brain Ischemia / prevention & control*
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CHO Cells
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Cell Death / drug effects
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Cell Survival / drug effects
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Cerium / administration & dosage
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Cerium / chemistry
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Cerium / pharmacology*
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Cricetinae
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Free Radical Scavengers / administration & dosage
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / pharmacology*
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Metal Nanoparticles / administration & dosage
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Metal Nanoparticles / chemistry*
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Rats
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Reactive Oxygen Species / metabolism
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Stroke / drug therapy
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Stroke / metabolism
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Stroke / prevention & control*
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Tissue Distribution
Substances
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Free Radical Scavengers
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Reactive Oxygen Species
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Cerium