In vivo two-photon fluorescent imaging of fluoride with a desilylation-based reactive probe

Chem Commun (Camb). 2012 Oct 21;48(82):10243-5. doi: 10.1039/c2cc35668f.

Abstract

A two-photon excitable molecular probe for fluoride, developed based on a fluoride-specific desilylation reaction, is demonstrated to be useful for fluorescent imaging of fluoride ions in live zebrafish by one-photon as well as two-photon microscopy for the first time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Fluorescence*
  • Fluorides / chemistry*
  • Mice
  • Molecular Probes / chemistry*
  • Molecular Structure
  • Organosilicon Compounds / chemistry*
  • Photons*
  • Zebrafish

Substances

  • Molecular Probes
  • Organosilicon Compounds
  • t-butyldimethylsilyl compounds
  • Fluorides