Competing risks with missing covariates: effect of haplotypematch on hematopoietic cell transplant patients

Lifetime Data Anal. 2013 Jan;19(1):19-32. doi: 10.1007/s10985-012-9229-1. Epub 2012 Sep 12.

Abstract

In this paper we consider a problem from hematopoietic cell transplant (HCT) studies where there is interest on assessing the effect of haplotype match for donor and patient on the cumulative incidence function for a right censored competing risks data. For the HCT study, donor's and patient's genotype are fully observed and matched but their haplotypes are missing. In this paper we describe how to deal with missing covariates of each individual for competing risks data. We suggest a procedure for estimating the cumulative incidence functions for a flexible class of regression models when there are missing data, and establish the large sample properties. Small sample properties are investigated using simulations in a setting that mimics the motivating haplotype matching problem. The proposed approach is then applied to the HCT study.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Graft vs Host Disease / etiology
  • HLA Antigens / genetics
  • Haplotypes*
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Hematopoietic Stem Cell Transplantation / mortality
  • Histocompatibility Testing
  • Humans
  • Life Tables
  • Models, Statistical
  • Proportional Hazards Models
  • Regression Analysis
  • Risk Factors

Substances

  • HLA Antigens