Abstract
During the dynamic assembly and activation of the spliceosome, human pre-mRNA processing factor 19 (hPrp19) plays a major role alone or as a part of a protein complex. In addition to participating in post-transcriptional regulation of eukaryotic gene, hPrp19 takes part in many physiological events such as ubiquitin-proteasome system, DNA damage response, proliferation and apoptosis. Increasing evidence also indicates a potential role of hPrp19 during oncogenesis, possibly owing to its activity of repressing apoptosis. Together, these studies add a new dimension to our understanding of hPrp19, and we have reason to believe that continuing excavation of this multi-faceted protein may shed light on its roles in human diseases, especially in cancer.
Copyright © 2012 Soçiété Francaise des Microscopies and Société de Biologie Cellulaire de France.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Apoptosis*
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Cell Proliferation
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / metabolism*
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Cell Transformation, Neoplastic / pathology
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DNA Damage
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DNA Repair Enzymes / genetics
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DNA Repair Enzymes / metabolism*
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Gene Expression Regulation, Neoplastic / genetics
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Humans
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Neoplasm Proteins / genetics
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Neoplasm Proteins / metabolism*
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Neoplasms / enzymology*
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Neoplasms / genetics
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Neoplasms / pathology
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism*
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Proteasome Endopeptidase Complex / genetics
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Proteasome Endopeptidase Complex / metabolism
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RNA Splicing Factors
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Spliceosomes / genetics
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Spliceosomes / metabolism*
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Ubiquitin / genetics
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Ubiquitin / metabolism
Substances
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Neoplasm Proteins
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Nuclear Proteins
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RNA Splicing Factors
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Ubiquitin
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Proteasome Endopeptidase Complex
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DNA Repair Enzymes
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PRPF19 protein, human