Radiation responses and resistance

Int Rev Cell Mol Biol. 2012:299:235-53. doi: 10.1016/B978-0-12-394310-1.00006-0.

Abstract

The cytotoxic effect of ionizing radiation makes it a popular therapeutic tool against cancer. It is, however, a double-edged sword. Radiation exposure unleashes a plethora of protective and survival mechanisms that include increased proliferation, remodeling of the vasculature and altered cell motility. These mechanisms can play a pro-survival role in remaining cells, contributing to repopulation of tumors after radiation treatment. Understanding these mechanisms and finding ways to minimize their impact would improve the outcome of radiotherapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Proliferation / radiation effects
  • Cell Survival / radiation effects
  • Humans
  • Neoplasms / pathology
  • Neoplasms / radiotherapy*
  • Radiation Tolerance / radiation effects*
  • Radiation, Ionizing*