Antibasal Ganglia Antibodies and Antistreptolysin O in Noncomorbid ADHD

J Atten Disord. 2015 Nov;19(11):965-70. doi: 10.1177/1087054712455505. Epub 2012 Sep 5.

Abstract

Objective: An association between streptococcal infections, ABGA positivity, and no comorbidity ADHD (nc-ADHD) has been little investigated. The aim of this study was to evaluate the streptococcal infection frequency, defined entitled serum antistreptolysin O (ASO), and frequency of serum ABGA positivity in a sample of patients with nc-ADHD.

Method: In all 40 participants were investigated the ASO titer and ABGA.

Results: The results showed that ABGA positivity was statistically significantly higher in patients affected by ADHD than in patients of a control group, and pathological values of ASO were statistically more frequent in the ADHD group than the control group.

Conclusion: These data suggest that streptococcal infections and autoimmune reactions against the basal ganglia are more frequent in ADHD patients than patients in a control group.

Keywords: ADHD; antibasal ganglia antibodies; antistreptolysin O.

MeSH terms

  • Adolescent
  • Antibodies, Bacterial / analysis*
  • Antistreptolysin / analysis*
  • Attention Deficit Disorder with Hyperactivity / epidemiology
  • Attention Deficit Disorder with Hyperactivity / immunology*
  • Attention Deficit Disorder with Hyperactivity / microbiology
  • Autoantibodies / blood
  • Autoantibodies / immunology
  • Basal Ganglia / immunology*
  • Biomarkers / analysis
  • Biomarkers / blood
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Immunologic Factors*
  • Male
  • Prevalence
  • Streptococcal Infections / diagnosis*
  • Streptococcal Infections / epidemiology
  • Streptococcal Infections / immunology

Substances

  • Antibodies, Bacterial
  • Autoantibodies
  • Biomarkers
  • Immunologic Factors
  • Antistreptolysin