Abstract
Five novel compounds were isolated from the water extract of Tabebuia avellanedae, and their structures were established by analysis of NMR spectroscopy and mass spectrometry. Compounds 1-5 at 25μM showed strong inhibitory activity on the inflammatory cytokine, tumor-necrosis factor-α and interleukin-1β production in cultured human myeloma THP-1 cells co-stimulated with lipopolysaccharide without any significant cytotoxicity, and their anti-allergic and antioxidant activities were evaluated.
Copyright © 2012 Elsevier B.V. All rights reserved.
MeSH terms
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / pharmacology*
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Biphenyl Compounds
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Cell Line
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Free Radical Scavengers / pharmacology
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Gene Expression Regulation / drug effects
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Humans
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Interleukin-1beta / genetics
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Interleukin-1beta / metabolism
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Molecular Structure
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Picrates
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology*
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Tabebuia / chemistry*
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Tumor Necrosis Factor-alpha / genetics
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Tumor Necrosis Factor-alpha / metabolism
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beta-N-Acetylhexosaminidases / genetics
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beta-N-Acetylhexosaminidases / metabolism
Substances
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Anti-Inflammatory Agents
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Biphenyl Compounds
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Free Radical Scavengers
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Interleukin-1beta
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Picrates
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Plant Extracts
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Tumor Necrosis Factor-alpha
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1,1-diphenyl-2-picrylhydrazyl
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beta-N-Acetylhexosaminidases