Anti-inflammatory constituents from Tabebuia avellanedae

Fitoterapia. 2012 Dec;83(8):1484-8. doi: 10.1016/j.fitote.2012.08.014. Epub 2012 Aug 29.

Abstract

Five novel compounds were isolated from the water extract of Tabebuia avellanedae, and their structures were established by analysis of NMR spectroscopy and mass spectrometry. Compounds 1-5 at 25μM showed strong inhibitory activity on the inflammatory cytokine, tumor-necrosis factor-α and interleukin-1β production in cultured human myeloma THP-1 cells co-stimulated with lipopolysaccharide without any significant cytotoxicity, and their anti-allergic and antioxidant activities were evaluated.

MeSH terms

  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / pharmacology*
  • Biphenyl Compounds
  • Cell Line
  • Free Radical Scavengers / pharmacology
  • Gene Expression Regulation / drug effects
  • Humans
  • Interleukin-1beta / genetics
  • Interleukin-1beta / metabolism
  • Molecular Structure
  • Picrates
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology*
  • Tabebuia / chemistry*
  • Tumor Necrosis Factor-alpha / genetics
  • Tumor Necrosis Factor-alpha / metabolism
  • beta-N-Acetylhexosaminidases / genetics
  • beta-N-Acetylhexosaminidases / metabolism

Substances

  • Anti-Inflammatory Agents
  • Biphenyl Compounds
  • Free Radical Scavengers
  • Interleukin-1beta
  • Picrates
  • Plant Extracts
  • Tumor Necrosis Factor-alpha
  • 1,1-diphenyl-2-picrylhydrazyl
  • beta-N-Acetylhexosaminidases