Synthesis of pyrrolo[2,3-b]indole via iodine(III)-mediated intramolecular annulation

Org Lett. 2012 Sep 21;14(18):4830-3. doi: 10.1021/ol302158h. Epub 2012 Sep 6.

Abstract

New synthetic procedures for the pyrrolo[2,3-b]indole skeleton have been developed via intramolecular annulation of indole derivatives under iodine(III). A series of indole derivatives with different protecting groups or substitutions were explored to facilitate the corresponding pyrrolo[2,3-b]indole compounds in excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Cyclization
  • Hydrocarbons, Iodinated / chemistry*
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Molecular Structure
  • Pyrroles / chemical synthesis*
  • Pyrroles / chemistry

Substances

  • Hydrocarbons, Iodinated
  • Indoles
  • Pyrroles