Herpes simplex viruses: mechanisms of DNA replication

Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a013011. doi: 10.1101/cshperspect.a013011.

Abstract

Herpes simplex virus (HSV) encodes seven proteins necessary for viral DNA synthesis-UL9 (origin-binding protein), ICP8 (single-strand DNA [ssDNA]-binding protein), UL30/UL42 (polymerase), and UL5/UL8/UL52 (helicase/primase). It is our intention to provide an up-to-date analysis of our understanding of the structures of these replication proteins and how they function during HSV replication. The potential roles of host repair and recombination proteins will also be discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • DNA Replication / physiology*
  • DNA-Directed DNA Polymerase / chemistry
  • DNA-Directed DNA Polymerase / physiology
  • Genome, Viral
  • Models, Genetic*
  • Protein Structure, Tertiary
  • Replication Origin
  • Simplexvirus / genetics*
  • Simplexvirus / physiology
  • Viral Proteins / chemistry
  • Viral Proteins / physiology*
  • Virus Replication / physiology*

Substances

  • Viral Proteins
  • DNA-Directed DNA Polymerase