Light-regulated host-guest interaction as a new strategy for intracellular PEG-detachable polyplexes to facilitate nuclear entry

Chem Commun (Camb). 2012 Oct 18;48(81):10126-8. doi: 10.1039/c2cc34768g.

Abstract

PEG-detachable polyplexes were constructed for the first time via host-guest interactions between β-cyclodextrin and azobenzene. The polyplexes had excellent colloidal stability and competition stability. Moreover, the intracellular light-regulated dePEGylation facilitated DNA release and nuclear entry, thus resulting in efficient transfection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azo Compounds / chemistry*
  • Azo Compounds / metabolism
  • DNA / administration & dosage*
  • DNA / genetics
  • Drug Carriers / chemistry*
  • Drug Carriers / metabolism
  • HEK293 Cells
  • Hep G2 Cells
  • Humans
  • Light
  • Polyethylene Glycols / chemistry*
  • Polyethylene Glycols / metabolism
  • Transfection*
  • beta-Cyclodextrins / chemistry*
  • beta-Cyclodextrins / metabolism

Substances

  • Azo Compounds
  • Drug Carriers
  • beta-Cyclodextrins
  • Polyethylene Glycols
  • DNA
  • azobenzene
  • betadex