An excellent enzymatic lactic acid biosensor with ZnO nanowires-gated AlGaAs/GaAs high electron mobility transistor

Nanoscale. 2012 Oct 21;4(20):6415-8. doi: 10.1039/c2nr31708g.

Abstract

An excellent biosensor with ZnO nanowires-gated AlGaAs/GaAs high electron mobility transistor (HEMT) was used to detect lactic acid. Due to the new structure, addition of the Si-doped GaAs cap layer, the HEMT biosensor could detect a wide range of lactic acid concentrations from 0.03 nM to 300 mM. The novel biosensor exhibiting good performance along with fast response, high sensitivity, wide detection range, and long-term stability, can be integrated with a commercially available transmitter to realize lactic acid detection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aluminum / chemistry*
  • Arsenicals / chemistry*
  • Biosensing Techniques / instrumentation*
  • Biosensing Techniques / methods
  • Enzymes, Immobilized / chemistry*
  • Enzymes, Immobilized / metabolism
  • Gallium / chemistry*
  • Lactic Acid / analysis*
  • Lactic Acid / metabolism
  • Limit of Detection
  • Mixed Function Oxygenases / chemistry
  • Mixed Function Oxygenases / metabolism
  • Nanowires / chemistry*
  • Zinc Oxide / chemistry*

Substances

  • Arsenicals
  • Enzymes, Immobilized
  • gallium arsenide
  • Lactic Acid
  • Gallium
  • Aluminum
  • Mixed Function Oxygenases
  • lactate 2-monooxygenase
  • Zinc Oxide