Measurement of barrier tissue integrity with an organic electrochemical transistor

Leslie H Jimison; Scherrine A Tria; Dion Khodagholy; Moshe Gurfinkel; Erica Lanzarini; Adel Hama; George G Malliaras; Róisín M Owens

doi:10.1002/adma.201202612

Measurement of barrier tissue integrity with an organic electrochemical transistor

Adv Mater. 2012 Nov 20;24(44):5919-23. doi: 10.1002/adma.201202612. Epub 2012 Sep 5.

Authors

Leslie H Jimison¹, Scherrine A Tria, Dion Khodagholy, Moshe Gurfinkel, Erica Lanzarini, Adel Hama, George G Malliaras, Róisín M Owens

Affiliation

¹ Department of Bioelectronics, Ecole Nationale Superieure des Mines, CMP-EMSE, MOC, 880 Rue de Mimet, Gardanne 13541, France.

PMID: 22949380
DOI: 10.1002/adma.201202612

Abstract

The integration of an organic electrochemical transistor with human barrier tissue cells provides a novel method for assessing toxicology of compounds in vitro. Minute variations in paracellular ionic flux induced by toxic compounds are measured in real time, with unprecedented temporal resolution and extreme sensitivity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Assay / instrumentation*
Biosensing Techniques / instrumentation*
Caco-2 Cells
Cell Survival / drug effects*
Equipment Design
Equipment Failure Analysis
Ethanol / toxicity*
Humans
Hydrogen Peroxide / toxicity*
Organic Chemicals / chemistry
Transistors, Electronic*

Substances

Organic Chemicals
Ethanol
Hydrogen Peroxide