Abstract
Perturbation of hydroxyl radical accumulation by subinhibitory concentrations of 2,2'-bipyridyl plus thiourea protects Escherichia coli from being killed by 3 lethal antimicrobial classes. Here, we show that 2,2'-bipyridyl plus thiourea delays and/or reduces antimicrobial killing of Staphylococcus aureus by daptomycin, moxifloxacin, and oxacillin. While the protective effect of 2,2'-bipyridyl plus thiourea varied among strains and compounds, the data support the hypothesis that hydroxyl radical enhances antimicrobial lethality.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
2,2'-Dipyridyl / pharmacology
-
Anti-Bacterial Agents / antagonists & inhibitors
-
Anti-Bacterial Agents / pharmacology*
-
Aza Compounds / antagonists & inhibitors
-
Aza Compounds / pharmacology*
-
Daptomycin / antagonists & inhibitors
-
Daptomycin / pharmacology*
-
Fluoroquinolones
-
Microbial Sensitivity Tests
-
Moxifloxacin
-
Oxacillin / antagonists & inhibitors
-
Oxacillin / pharmacology*
-
Quinolines / antagonists & inhibitors
-
Quinolines / pharmacology*
-
Reactive Oxygen Species / antagonists & inhibitors
-
Reactive Oxygen Species / metabolism*
-
Staphylococcus aureus / drug effects*
-
Staphylococcus aureus / growth & development
-
Thiourea / pharmacology
-
Time Factors
Substances
-
Anti-Bacterial Agents
-
Aza Compounds
-
Fluoroquinolones
-
Quinolines
-
Reactive Oxygen Species
-
2,2'-Dipyridyl
-
Thiourea
-
Daptomycin
-
Moxifloxacin
-
Oxacillin